Prolonged Infusion of Dexmedetomidine in Critically-ill Children.
نویسندگان
چکیده
OBJECTIVE To describe main indications, doses, length of infusion and side effects related to dexmedetomidine infusion. METHODS Observational and retrospective study evaluating dexmedetomidine use in pediatric intensive care unit. RESULTS 77 children received dexmedetomidine infusion longer than 6 hours for mechanical ventilation weaning (32.5%), post- neurosurgery and post-upper airway surgery (24.7%), non-invasive ventilation (13%), refractory tachycardia (6.5%) and other causes (23.3%). After 6 hours of infusion, significant decrease in mean arterial pressure and heart rate was observed in all groups. Six children (8%) required withdrawal of drug because of possible side effects: hypotension, bradycardia and somnolence. CONCLUSION Dexmedetomidine may be used as sedative in critically ill children without much side effects.
منابع مشابه
Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients
INTRODUCTION Only limited information exists on the pharmacokinetics of prolonged (> 24 hours) and high-dose dexmedetomidine infusions in critically ill patients. The aim of this study was to characterize the pharmacokinetics of long dexmedetomidine infusions and to assess the dose linearity of high doses. Additionally, we wanted to quantify for the first time in humans the concentrations of H-...
متن کاملProlonged dexmedetomidine infusions in critically ill infants and children.
OBJECTIVE To present our institutional experience with prolonged dexmedetomidine (DEX) infusions in critically ill infants and children. DESIGN Retrospective medical chart review between January 1, 2007 and December 1, 2007. SETTING Tertiary care pediatric teaching hospital. PARTICIPANTS Infants and children (up to 18 years of age) who received DEX for a duration greater than 24 hours. ...
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BACKGROUND Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine over time. METHODS We performed a retrospective cohort study of all patients who received intravenous infusion sedation in 174 intensive care un...
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BACKGROUND AND OBJECTIVES Although the pharmacokinetics of dexmedetomidine in healthy volunteers have been studied, there are limited data about the pharmacokinetics of long-term administration of dexmedetomidine in critically ill patients. METHODS This population pharmacokinetic analysis was performed to quantify the pharmacokinetics of dexmedetomidine in critically ill patients following in...
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SEDATION IN INTENSIVE CARE PAtients is assumed to reduce discomfort from care interventions, increase tolerance of mechanical ventilation, prevent accidental removal of instrumentation, and reduce metabolic demands during cardiovascular and respiratory instability. Long-term sedation may have serious adverse effects, such as prolonged mechanical ventilation, coma, delirium, delusional memories ...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 53 11 شماره
صفحات -
تاریخ انتشار 2016